Language

CAS No.20537-88-6 | Amifostine

CAS No. 20537-88-6 MF:C5H15N2O3PS MW:214.22 Purity:98% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

Categories：

Other Life Science Chemicals

Email：sale06@alfachem.cn

Inquiry

Chat Now

Product introduction

Introduction and application of CAS No.20537-88-6 | Amifostine

Synonyms:2-(3-Aminopropyl)aminoethylphosphorothioate,WR2721;

S-2-[(3-Aminopropyl)amino]ethanethioldihydrogenphosphateester;

Amifostine,2-(3-Aminopropyl)aminoethylphosphorothioate,WR2721;

Specification:

ITEMS	SPECIFICATION
CAS	20537-88-6
MF	C5H15N2O3PS
MW	214.22
Melting point	160-161°C
Boiling point	441.7±51.0 °C
Density	1.367±0.06 g/cm3
Acidity coefficient	1.28±0.10
Color	White
Solubility	soluble in water.
Form	Powder
Storage condition	2-8°C

Indications:

This product is a normal cell protective agent, mainly used for adjuvant treatment of various cancers. Applying this product before chemotherapy to patients with lung cancer, ovarian cancer, breast cancer, nasopharyngeal cancer, bone tumors, digestive tract tumors, blood system tumors and other cancers can significantly reduce the damage caused by chemotherapy drugs to the kidneys, bone marrow, heart, Ear and nervous system toxicity without reducing the efficacy of chemotherapy drugs. Applying this product before radiotherapy can significantly reduce the occurrence of dry mouth and mucositis.

Chemical properties:

Melting point 160~161℃. Monohydrate: [63717-27-1]. A white solid is obtained from methanol-diethyl ether, with a melting point of 160-161°C (decomposition). Easily soluble in water, but unstable, especially unstable in acidic aqueous solutions, it will dephosphorylate.

use:

Chemotherapy cytoprotective agents and radiotherapy protective agents can selectively protect normal tissue cells when killing cancer cells during radiotherapy or chemotherapy, allowing patients to continue receiving treatment. It is used to detoxify the kidneys of anti-cancer drugs, prevent side effects such as hematopoietic system and immune damage caused by radiotherapy, and has a certain effect. It is also used to reduce infections related to neutropenia. Usage Cytoprotective agent, used to protect kidney, bone marrow and heart during chemotherapy

production method:

Method 1: Propylenediamine reacts with ethylene oxide to generate N-hydroxyethylpropanediamine, and then reacts with 40% hydrobromic acid to generate dihydrobromide of N-(2-bromoethyl)propanediamine. acid salt, and finally reacts with sodium thiophosphate 10hydrate to obtain amifostine monohydrate.

Method 2: Compound (Ⅰ) reacts with compound (Ⅱ), and the product (Ⅲ) is converted into compound (Ⅳ) and compound (V) by using hydrobromic acid-acetic acid, and then reacts with (Ⅵ) to obtain ammonium phosphorus Ting.

Package and transportation :

Package: 5g,25g,200g,500g,1kg